Cart
sales@molnova.com
Home - Products - Angiogenesis - Adrenergic Receptor - JP1302 dihydrochloride

JP1302 dihydrochloride

CAS No. 1259314-65-2

JP1302 dihydrochloride( —— )

Catalog No. M26267 CAS No. 1259314-65-2

JP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Ki (binding affinity) value of 28 nM and a Kb value (antagonist activity) of 16 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 49 Get Quote
5MG 79 Get Quote
10MG 116 Get Quote
25MG 222 Get Quote
50MG 358 Get Quote
100MG 533 Get Quote
500MG 1152 Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    JP1302 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    JP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Ki (binding affinity) value of 28 nM and a Kb value (antagonist activity) of 16 nM.
  • Description
    JP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Ki (binding affinity) value of 28 nM and a Kb value (antagonist activity) of 16 nM.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Sprague Dawley rats (8 weeks old)Dosage:3 mg/kg Administration:IV, pre-treatment: administered 5 min before the induction of ischemia, post-treatment: injected 45 min after the initiation of reperfusion Result:Significantly ameliorated renal dysfunction in the rats at 24 h after reperfusion. post-ischemic administration of JP-1302 significantly ameliorated renal dysfunction, histological damage and reduced apoptotic cells and pro-inflammatory cytokine mRNA expression.
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    Adrenergic Receptor
  • Recptor
    NF-κB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1259314-65-2
  • Formula Weight
    441.4
  • Molecular Formula
    C24H26Cl2N4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 12.5 mg/mL (28.32 mM)
  • SMILES
    Cl.Cl.CN1CCN(CC1)c1ccc(Nc2c3ccccc3nc3ccccc23)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bouguerra, G., et al. Stimulation of Eryptosis by Narasin. Cellular Physiology and Biochemistry. 2015; 37(5):1807-1816.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Phentolamine

    Phentolamine mesylate is an alpha-1 and alpha-2 selective adrenergic receptor antagonist.

  • Naringenin chalcone

    Naringenin chalcone has antiallergic activity .Naringenin chalcone suppresses asthmatic symptoms by inhibiting Th2 cytokine production from CD4 T cells.

  • Medetomidine

    A potent, highly selective α2-adrenoceptor agonist with Ki of 1.08 nM; used as both a surgical anesthetic and analgesic.

Sign In Join Free