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JP1302 dihydrochloride
CAS No. 1259314-65-2
JP1302 dihydrochloride( —— )
Catalog No. M26267 CAS No. 1259314-65-2
JP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Ki (binding affinity) value of 28 nM and a Kb value (antagonist activity) of 16 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 49 | Get Quote |
|
| 5MG | 79 | Get Quote |
|
| 10MG | 116 | Get Quote |
|
| 25MG | 222 | Get Quote |
|
| 50MG | 358 | Get Quote |
|
| 100MG | 533 | Get Quote |
|
| 500MG | 1152 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameJP1302 dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionJP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Ki (binding affinity) value of 28 nM and a Kb value (antagonist activity) of 16 nM.
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DescriptionJP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Ki (binding affinity) value of 28 nM and a Kb value (antagonist activity) of 16 nM.
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In Vitro——
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In VivoAnimal Model:Male Sprague Dawley rats (8 weeks old)Dosage:3 mg/kg Administration:IV, pre-treatment: administered 5 min before the induction of ischemia, post-treatment: injected 45 min after the initiation of reperfusion Result:Significantly ameliorated renal dysfunction in the rats at 24 h after reperfusion. post-ischemic administration of JP-1302 significantly ameliorated renal dysfunction, histological damage and reduced apoptotic cells and pro-inflammatory cytokine mRNA expression.
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Synonyms——
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PathwayAngiogenesis
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TargetAdrenergic Receptor
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RecptorNF-κB
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Research Area——
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Indication——
Chemical Information
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CAS Number1259314-65-2
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Formula Weight441.4
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Molecular FormulaC24H26Cl2N4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 12.5 mg/mL (28.32 mM)
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SMILESCl.Cl.CN1CCN(CC1)c1ccc(Nc2c3ccccc3nc3ccccc23)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bouguerra, G., et al. Stimulation of Eryptosis by Narasin. Cellular Physiology and Biochemistry. 2015; 37(5):1807-1816.
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